Event Information

In Person Ride

Sunday, September 18, 2022

Daniel Boone Homestead


The Breakthrough Challenge was founded in 2013. Our goal is to raise funds supporting breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center by uniting for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley.

There are 3 bike route options (50, 25 and 12 miles) to select from and more details of these routes will be available soon.

Leading up to the in person bike ride, participants can join virtual events from Monday, September 5 –  Sunday, September 18, 2022 for cyclists, spinners, runners and walkers on the Strava app.  

Since 2013, our ride has donated more than $1,925,000 to support these breakthroughs. Learn more about our cause.


Additional event details for both the in person and virual options will be added as they become available, please check back at a later date.