Event Day Information

In Person Ride

Sunday, September 10, 2023

Daniel Boone Homestead

The Breakthrough Challenge was founded in 2013. Our goal is to raise funds supporting breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center by uniting for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley.

There are 3 bike route options (50, 25 and 12 miles). 

Please note: Routes are subject to change.  Be sure to visit our website on Sept. 8th for the most up-to-date route info.

50 mile https://ridewithgps.com/routes/37082964

25 mile  https://ridewithgps.com/routes/37083037

12 mile https://ridewithgps.com/routes/37083062

Start Times

50 mile: arrive by 8:00 am*

25 mile: arrive by 9:30 am*

12 mile: arrive by 10:30 am*

*Please be prepared to have wheels on the ground and ready to ride by the designated start time.

Venue Details



Please note there is a 10 mph vehicle speed limit within Daniel Boone Homestead.



Click here for Road & Safety Tips


POST RIDE LUNCH - 11:15 am to 2:00 pm

Complimentary lunch will be catered by food trucks immediately following the ride (vegetarian and vegan options will be available!)


If you own an Epi Pen, please do not forget to bring it with you.

Virtual Challenges

Leading up to the in person bike ride, participants can join virtual challenges from Monday, September 4 –  Sunday, September 10, 2023 for cyclists, spinners, runners and walkers on the Strava app.  

Since 2013, our ride has donated more than $2,225,000 to support these breakthroughs. Learn more about our cause.

Additional event details for both the in person and virual options will be added as they become available, please check back at a later date.